Fig 1: Confocal microscopy analysis of CPP internalisation after 1 h of co-incubation of the blood with FITC-labeled MPPs, CPP-P, CPP-S, or control PBS solution under flow (15 dyn/cm2 shear stress). Differential isolation of blood cell populations and subsequent immunostaining (CD45, CD235a, and CD41 are specific markers of leukocytes, red blood cells, and platelets, respectively, stained red). Note that the particles (stained green) are internalised by monocytes (marked by yellow circles) but not lymphocytes (distinguishable by a nuclear shape) upon the Ficoll gradient centrifugation isolation. Co-localisation of the particles (stained green) with the lysosomes (stained by LysoTracker Red) in the ECs is notable for orange or yellow colour. Magnification: ×400, scale bar: 25 µm.